{"id":3857,"date":"2021-07-14T15:45:44","date_gmt":"2021-07-14T19:45:44","guid":{"rendered":"https:\/\/www.diex.ca\/?p=3857"},"modified":"2021-07-14T16:40:24","modified_gmt":"2021-07-14T20:40:24","slug":"development-of-a-new-treatment-for-fatty-liver-disease","status":"publish","type":"post","link":"https:\/\/www.diex.ca\/en\/2021\/07\/14\/development-of-a-new-treatment-for-fatty-liver-disease\/","title":{"rendered":"Development of a new treatment for \u201cfatty liver disease\u201d"},"content":{"rendered":"

DIEX Research<\/strong><\/span><\/p>\r\n

Development of a new treatment<\/strong><\/span><\/p>\r\n

for \u201cfatty liver disease\u201d<\/strong><\/span><\/p>\r\n

\u00a0<\/strong><\/p>\r\n

Quebec City,\u00a014-07-2021\u2014DIEX Research, a world-class Quebec-based company that conducts high-quality clinical research, is currently involved in the development of an experimental treatment for \u201cfatty liver disease,\u201d or non-alcoholic fatty liver disease, which affects as many as one in five Canadians, including a growing number of children.<\/em><\/p>\r\n

Thanks to DIEX\u2019s expertise in the Quebec City area and the financial support of the pharmaceutical company Pfizer, sponsor of the study, DIEX has been able to put together a team of specialized professionals who will spend the next few months conducting in-depth research on this disease for which there is still no satisfactory treatment.<\/p>\r\n

\u201cThis kind of study will completely change the way we treat the disease in the future,\u201d says Dr.\u00a0Pascale Chouinard, the study\u2019s principal investigator and a gastroenterologist, FRCPC, with a subspecialty in hepatology.<\/p>\r\n

The study is evaluating the efficacy of two experimental oral medications. A first molecule is either administered alone or the same molecule is co-administered with a second molecule. The efficacy of the drugs is then evaluated, in particular by liver biopsies (samples of the liver). This is the first study of its kind to be conducted. \u201cWe are in Phase\u00a0II, says Dr. Chouinard. Phase I has shown promising preliminary results, which gives us great hope for the future.\u201d<\/p>\r\n

A Difficult Disease to Diagnose<\/strong><\/p>\r\n

A specific subset of non-alcoholic fatty liver disease, called non-alcoholic steatohepatitis or NASH, results from the accumulation of fat in the liver cells, usually due to overconsumption of sugars and fats. This accumulation of fat causes liver inflammation and liver damage, and eventually leads to cirrhosis, the final stage of the disease. And when the damage becomes too severe, the only solution is to perform a liver transplant.<\/p>\r\n

NASH is also associated with an increased risk of cardiovascular disease and leads to a deterioration in the quality of life of individuals, from fatigue to severe clinical symptoms. This is why it is important to treat it as early as possible.<\/p>\r\n

The problem is that NASH is a silent disease and is most often diagnosed too late. \u201cFirst of all, it doesn\u2019t cause any specific signs or symptoms,\u201d explains Dr. Chouinard. When the first signs appear, it is often too late, the disease is well established. The first signs are fatigue, jaundice, edema or digestive bleeding. \u201cBlood tests and medical imaging can identify liver abnormalities,\u201d says the gastroenterologist.<\/p>\r\n


\r\nBut these tests are not enough to make a diagnosis. The only effective way to detect the disease is a liver biopsy.<\/p>\r\n

Canada\u2019s First Clinical Research Study with Pfizer<\/strong><\/p>\r\n

To conduct the study, Pfizer provided DIEX with a FibroScan\u00ae, a device that quantifies liver fibrosis non-invasively, allowing for a painless examination. This device is generally only available in hospitals.<\/p>\r\n

Thus, DIEX is the only clinical research centre in Canada, in collaboration with Pfizer, capable of conducting such research outside the hospital setting. The company relies on the expertise of its team of seasoned professionals, its scientific rigour and its creativity. Well-equipped to meet the challenges of developing new solutions for various diseases, DIEX is also currently conducting several other innovative studies, including the development of a plant-based vaccine against COVID-19 for the pharmaceutical company Medicago.<\/p>\r\n

Opportunity to participate in the clinical study<\/strong><\/p>\r\n

Anyone with liver disease may be eligible to participate in this study conducted by DIEX.<\/p>\r\n


\r\n\u00a0Interested individuals will be assessed by telephone by a recruitment specialist. If successful, they may then go through a screening process to determine eligibility for the clinical study.<\/p>\r\n

The company is located at 205 Montmagny Street, Suite 102-103, Quebec City. Anyone interested can contact DIEX at 581-477-3439 or toll-free at 1-844-739-3439, or by email at info@diex.ca. For more information about the company: www.diex.ca.<\/p>\r\n

Communiqu\u00e9 presse NASH- EN<\/a><\/p>","protected":false},"excerpt":{"rendered":"

DIEX Research
\nDevelopment of a new treatment
\nfor \u201cfatty liver disease\u201d
\n\u00a0
\nQuebec City,\u00a014-07-2021\u2014DIEX Research, a world-class Quebec-based company that conducts high-quality clinical research, is […]<\/p>\n","protected":false},"author":10,"featured_media":3861,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-3857","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"\nDevelopment of a new treatment for \u201cfatty liver disease\u201d - Diex Recherche<\/title>\n<meta name=\"description\" content=\"DIEX Research Development of a new treatment for \u201cfatty liver disease\u201d \u00a0 Quebec City,\u00a014-07-2021\u2014DIEX Research, a world-class Quebec-based company that\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.diex.ca\/en\/2021\/07\/14\/development-of-a-new-treatment-for-fatty-liver-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Development of a new treatment for \u201cfatty liver disease\u201d - 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